Synthesis of 3-Diaminomethylene-2(3H)-furanones by Reaction of 2-Amino-4,5-dihydro-3-furancarboxamides with Amines

被引：0

作者：

Kenji Yamagata

Fumi Okabe

Motoyoshi Yamazaki

Yoshinobu Tagawa

机构：

[1] Faculty of Pharmaceutical Sciences,

[2] Fukuoka University,undefined

[3] 814-0180 Fukuoka,undefined

[4] Japan,undefined

来源：

Monatshefte für Chemie / Chemical Monthly | 2002年 / 133卷

关键词：

Keywords. Furancarboxamides; Furanones; Amines; Michael addition; Recyclization.;

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学科分类号：

摘要：

The reaction of 2-amino-4,5-dihydro-3-furancarboxamides with morpholine in the presence of acetic acid in pyridine or under the influence of ammonium acetate gave the corresponding 3-diaminomethylene-4,5-dihydro-2(3H )-furanones; 4,5-dihydro-2-morpholino-3-furancarboxamides were not isolated. One of the former reacted with benzylamine to give (E )- and (Z )-3-(amino-(benzylamino)-methylene)-4,5-dihydro-4-phenyl-2(3H )-furanones and 2-benzylamino-4,5-dihydro-4-phenyl-3-furancarboxamide.

引用

页码：643 / 651

页数：8