In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium

被引:0
作者
Laurent Yvernogeau
Rodolphe Gautier
Laurence Petit
Hanane Khoury
Frédéric Relaix
Vanessa Ribes
Helen Sang
Pierre Charbord
Michèle Souyri
Catherine Robin
Thierry Jaffredo
机构
[1] Sorbonne Université,IBPS, Laboratoire de Biologie du Développement CNRS UMR7622, Inserm U1156
[2] Institut Mondor de Recherches Biomédicales,The Roslin Institute and R(D)SVS
[3] Institut Jacques Monod,Regenerative Medicine Center
[4] University of Edinburgh,undefined
[5] Hubrecht Institute,undefined
[6] University Medical Center Utrecht,undefined
[7] Hubrecht Institute,undefined
[8] UMRS 1131,undefined
[9] Institut Universitaire d’Hématologie,undefined
[10] Hôpital Saint Louis,undefined
来源
Nature Cell Biology | 2019年 / 21卷
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摘要
It is well established that haematopoietic stem and progenitor cells (HSPCs) are generated from a transient subset of specialized endothelial cells termed haemogenic, present in the yolk sac, placenta and aorta, through an endothelial-to-haematopoietic transition (EHT). HSPC generation via EHT is thought to be restricted to the early stages of development. By using experimental embryology and genetic approaches in birds and mice, respectively, we document here the discovery of a bone marrow haemogenic endothelium in the late fetus/young adult. These cells are capable of de novo producing a cohort of HSPCs in situ that harbour a very specific molecular signature close to that of aortic endothelial cells undergoing EHT or their immediate progenies, i.e., recently emerged HSPCs. Taken together, our results reveal that HSPCs can be generated de novo past embryonic stages. Understanding the molecular events controlling this production will be critical for devising innovative therapies.
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页码:1334 / 1345
页数:11
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