The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones. Techniques for studying model plants such as Arabidopsis thaliana have enabled researchers to begin to uncover the pathways that establish and maintain chromatin modifications, and genomic studies are allowing the mapping of modifications such as DNA methylation on a genome-wide scale. Small RNAs seem to be important in determining the distribution of chromatin modifications, and RNA might also underlie the complex epigenetic interactions that occur between homologous sequences. Plants use these epigenetic silencing mechanisms extensively to control development and parent-of-origin imprinted gene expression.
机构:
Univ N Carolina, Howard Hughes Med Inst, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USAUniv N Carolina, Howard Hughes Med Inst, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
Martin, Cyrus
Zhang, Yi
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Univ N Carolina, Howard Hughes Med Inst, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USAUniv N Carolina, Howard Hughes Med Inst, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
机构:
Natl Inst Biol Sci, Beijing 102206, Peoples R China
Beijing Normal Univ, Life Sci Coll, Beijing 100875, Peoples R ChinaNatl Inst Biol Sci, Beijing 102206, Peoples R China
Yuan, Gang
Zhu, Bing
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Natl Inst Biol Sci, Beijing 102206, Peoples R ChinaNatl Inst Biol Sci, Beijing 102206, Peoples R China