Increased vulnerability of newly forming beta cells to cytokine-induced cell death

[1] Atkinson MA(2001)Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 358 221-229

[2] Eisenbarth GS(1965)Pathologic anatomy of the pancreas in juvenile diabetes mellitus Diabetes 14 619-633

[3] Gepts W(2005)Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48 2221-2228

[4] Meier JJ(2003)Inflammatory mediators and islet beta cell failure: a link between type 1 and type 2 diabetes J Mol Med 81 455-470

[5] Bhushan A(1997)Ex vivo expansion of human pancreatic endocrine cells J Clin Endocrinol Metab 82 1852-1856

[6] Butler AE(2002)FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication Proc Natl Acad Sci U S A 99 8236-8241

[7] Rizza RA(2003)Replication increases beta cell vulnerability to human islet amyloid polypeptide-induced apoptosis Diabetes 52 1701-1708

[8] Butler PC(2003)Increased beta cell apoptosis prevents adaptive increase in beta cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid Diabetes 52 2304-2314

[9] Donath MY(1989)Compensatory growth of pancreatic beta cells in adult rats after short-term glucose infusion Diabetes 38 49-53

[10] Storling J(1995)Dynamics of beta cell mass in the growing rat pancreas. Estimation with a simple mathematical model Diabetes 44 249-256

[1] Atkinson MA(2001)Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 358 221-229

[2] Eisenbarth GS(1965)Pathologic anatomy of the pancreas in juvenile diabetes mellitus Diabetes 14 619-633

[3] Gepts W(2005)Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48 2221-2228

[4] Meier JJ(2003)Inflammatory mediators and islet beta cell failure: a link between type 1 and type 2 diabetes J Mol Med 81 455-470

[5] Bhushan A(1997)Ex vivo expansion of human pancreatic endocrine cells J Clin Endocrinol Metab 82 1852-1856

[6] Butler AE(2002)FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication Proc Natl Acad Sci U S A 99 8236-8241

[7] Rizza RA(2003)Replication increases beta cell vulnerability to human islet amyloid polypeptide-induced apoptosis Diabetes 52 1701-1708

[8] Butler PC(2003)Increased beta cell apoptosis prevents adaptive increase in beta cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid Diabetes 52 2304-2314

[9] Donath MY(1989)Compensatory growth of pancreatic beta cells in adult rats after short-term glucose infusion Diabetes 38 49-53

[10] Storling J(1995)Dynamics of beta cell mass in the growing rat pancreas. Estimation with a simple mathematical model Diabetes 44 249-256