Genome-wide association study reveals two new risk loci for bipolar disorder

被引：0

作者：

Thomas W. Mühleisen

Markus Leber

Thomas G. Schulze

Jana Strohmaier

Franziska Degenhardt

Jens Treutlein

Manuel Mattheisen

Andreas J. Forstner

Johannes Schumacher

René Breuer

Sandra Meier

Stefan Herms

Per Hoffmann

André Lacour

Stephanie H. Witt

Andreas Reif

Bertram Müller-Myhsok

Susanne Lucae

Wolfgang Maier

Markus Schwarz

Helmut Vedder

Jutta Kammerer-Ciernioch

Andrea Pfennig

Michael Bauer

Martin Hautzinger

Susanne Moebus

Lutz Priebe

Piotr M. Czerski

Joanna Hauser

Jolanta Lissowska

Neonila Szeszenia-Dabrowska

Paul Brennan

James D. McKay

Adam Wright

Philip B. Mitchell

Janice M. Fullerton

Peter R. Schofield

Grant W. Montgomery

Sarah E. Medland

Scott D. Gordon

Nicholas G. Martin

Valery Krasnow

Alexander Chuchalin

Gulja Babadjanova

Galina Pantelejeva

Lilia I. Abramova

Alexander S. Tiganov

Alexey Polonikov

Elza Khusnutdinova

Martin Alda

机构：

[1] Institute of Human Genetics,Department of Genomics

[2] University of Bonn,Department of Psychiatry and Psychotherapy

[3] Life & Brain Center,Department of Genetic Epidemiology in Psychiatry

[4] University of Bonn,Department of Biomedicine

[5] Institute of Neuroscience and Medicine (INM-1),Division of Medical Genetics, Department of Biomedicine

[6] Research Centre Jülich,Department of Psychiatry

[7] Institute for Medical Biometry,Department of Translational Psychiatry

[8] Informatics,Department of Psychiatry

[9] and Epidemiology,Department of Psychiatry and Psychotherapy

[10] University of Bonn,Department of Psychology

[11] German Center for Neurodegenerative Diseases (DZNE),Department of Psychiatry

[12] Bonn,Department of Cancer Epidemiology and Prevention

[13] Germany,Department of Epidemiology

[14] University of Go¨ttingen,Department of Biology

[15] Central Institute of Mental Health,Department of Psychiatry

[16] Medical Faculty Mannheim/Heidelberg University,Department of Psychiatry

[17] Aarhus University,Department of Neurology and Neurosurgery

[18] Institute for Genomic Mathematics,Department of Psychiatry

[19] University of Bonn,Département des sciences fondamentales

[20] University of Basel,Department of Psychiatry

[21] Psychosomatics and Psychotherapy,undefined

[22] University of Würzburg,undefined

[23] Statistical Genetics,undefined

[24] Max Planck Institute of Psychiatry,undefined

[25] Munich Cluster for Systems Neurology (SyNergy),undefined

[26] Institute of Translational Medicine,undefined

[27] University of Liverpool,undefined

[28] University of Bonn,undefined

[29] Psychiatric Center Nordbaden,undefined

[30] University Hospital,undefined

[31] Clinical Psychology and Psychotherapy,undefined

[32] Eberhard Karls University Tübingen,undefined

[33] Institute of Medical Informatics,undefined

[34] Biometry,undefined

[35] and Epidemiology,undefined

[36] University Duisburg-Essen,undefined

[37] Poznan University of Medical Sciences,undefined

[38] Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology,undefined

[39] Nofer Institute of Occupational Medicine,undefined

[40] Genetic Epidemiology Group,undefined

[41] International Agency for Research on Cancer (IARC),undefined

[42] Genetic Cancer Susceptibility Group,undefined

[43] International Agency for Research on Cancer (IARC),undefined

[44] School of Psychiatry,undefined

[45] University of New South Wales,undefined

[46] Black Dog Institute,undefined

[47] Prince of Wales Hospital,undefined

[48] Neuroscience Research Australia,undefined

[49] School of Medical Sciences,undefined

[50] Faculty of Medicine,undefined

来源：

Nature Communications | / 5卷

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摘要：

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.

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