Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

被引:0
作者
Weihua Ren
Jianfeng Hou
Chenguang Yang
Hanjun Wang
Shuangting Wu
Yabin Wu
Xingpeng Zhao
Chao Lu
机构
[1] Zhengzhou University,Medical Examination Center, Luoyang Central Hospital
[2] Zhengzhou Central Hospital,Department of Oncology
[3] Kaifeng Central Hospital,Department of Oncology
[4] Imaging Department of Luoyang Orthopedic-traumatological Hospital,Department of Anesthesiology, Luoyang Central Hospital
[5] Zhengzhou University,undefined
来源
Journal of Experimental & Clinical Cancer Research | / 38卷
关键词
Mesenchymal stem cells; Extracellular vesicles; Hypoxia; miR-21-5p; Lung cancer; Macrophage polarization;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 120 条
[1]  
Bernardo ME(2013)Mesenchymal stromal cells: sensors and switchers of inflammation Cell Stem Cell 13 392-402
[2]  
Fibbe WE(2015)Stem cell therapies in clinical trials: progress and challenges Cell Stem Cell 17 11-22
[3]  
Trounson A(2015)Therapeutic applications of extracellular vesicles: clinical promise and open questions Annu Rev Pharmacol Toxicol 55 439-464
[4]  
McDonald C(2015)Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy Annu Rev Physiol 77 13-27
[5]  
Gyorgy B(2013)Extracellular vesicles: exosomes, microvesicles, and friends J Cell Biol 200 373-383
[6]  
Hung ME(2016)Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation Sci China Life Sci 59 1305-1312
[7]  
Breakefield XO(2017)Exosomal mir-146a contributes to the enhanced therapeutic efficacy of interleukin-1beta-primed mesenchymal stem cells against sepsis Stem Cells 35 1208-1221
[8]  
Leonard JN(2018)How to hit mesenchymal stromal cells and make the tumor microenvironment immunostimulant rather than immunosuppressive Front Immunol 9 262-52
[9]  
Kourembanas S(2017)Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets Nat Rev Drug Discov 16 35-76
[10]  
Raposo G(2018)Inhibitory effect and molecular mechanism of mesenchymal stem cells on NSCLC cells Mol Cell Biochem 441 63-44