Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease

被引：0
|
作者：
Jiansong Fang
Pengyue Zhang
Quan Wang
Chien-Wei Chiang
Yadi Zhou
Yuan Hou
Jielin Xu
Rui Chen
Bin Zhang
Stephen J. Lewis
James B. Leverenz
Andrew A. Pieper
Bingshan Li
Lang Li
Jeffrey Cummings
Feixiong Cheng
机构：
[1] Genomic Medicine Institute,Department of Biostatistics and Health Data Science, School of Medicine
[2] Lerner Research Institute,Department of Molecular Physiology and Biophysics
[3] Cleveland Clinic,Vanderbilt Genetics Institute
[4] Indiana University,Department of Biomedical Informatics, College of Medicine
[5] Vanderbilt University,Department of Pediatrics
[6] Vanderbilt University Medical Center,Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine
[7] Ohio State University,Harrington Discovery Institute
[8] Case Western Reserve University,Department of Psychiatry
[9] Case Western Reserve University,Institute for Transformative Molecular Medicine, School of Medicine
[10] Lou Ruvo Center for Brain Health,Department of Neuroscience
[11] Neurological Institute,Chambers
[12] Cleveland Clinic,Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences
[13] University Hospitals Cleveland Medical Center,undefined
[14] Case Western Reserve University,undefined
[15] Geriatric Psychiatry,undefined
[16] GRECC,undefined
[17] Louis Stokes Cleveland VA Medical Center,undefined
[18] Case Western Reserve University,undefined
[19] Case Western Reserve University,undefined
[20] School of Medicine,undefined
[21] University of Nevada Las Vegas,undefined
[22] Case Comprehensive Cancer Center,undefined
来源：
Alzheimer's Research & Therapy | / 14卷
关键词：
Alzheimer’s disease; Drug repurposing; Genome-wide association studies (GWAS); Multi-omics; Network medicine; Pioglitazone;
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