Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease

被引：0

作者：

Jiansong Fang

Pengyue Zhang

Quan Wang

Chien-Wei Chiang

Yadi Zhou

Yuan Hou

Jielin Xu

Rui Chen

Bin Zhang

Stephen J. Lewis

James B. Leverenz

Andrew A. Pieper

Bingshan Li

Lang Li

Jeffrey Cummings

Feixiong Cheng

机构：

[1] Genomic Medicine Institute,Department of Biostatistics and Health Data Science, School of Medicine

[2] Lerner Research Institute,Department of Molecular Physiology and Biophysics

[3] Cleveland Clinic,Vanderbilt Genetics Institute

[4] Indiana University,Department of Biomedical Informatics, College of Medicine

[5] Vanderbilt University,Department of Pediatrics

[6] Vanderbilt University Medical Center,Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine

[7] Ohio State University,Harrington Discovery Institute

[8] Case Western Reserve University,Department of Psychiatry

[9] Case Western Reserve University,Institute for Transformative Molecular Medicine, School of Medicine

[10] Lou Ruvo Center for Brain Health,Department of Neuroscience

[11] Neurological Institute,Chambers

[12] Cleveland Clinic,Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences

[13] University Hospitals Cleveland Medical Center,undefined

[14] Case Western Reserve University,undefined

[15] Geriatric Psychiatry,undefined

[16] GRECC,undefined

[17] Louis Stokes Cleveland VA Medical Center,undefined

[18] Case Western Reserve University,undefined

[19] Case Western Reserve University,undefined

[20] School of Medicine,undefined

[21] University of Nevada Las Vegas,undefined

[22] Case Comprehensive Cancer Center,undefined

来源：

Alzheimer's Research & Therapy | / 14卷

关键词：

Alzheimer’s disease; Drug repurposing; Genome-wide association studies (GWAS); Multi-omics; Network medicine; Pioglitazone;

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