Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD)

被引：0
|
作者：
Toni T. Seppälä
Mev Dominguez-Valentin
Julian R. Sampson
Pål Møller
机构：
[1] Helsinki University Hospital,Department of Surgery
[2] Johns Hopkins University,Department of Surgical Oncology
[3] The Norwegian Radium Hospital,Department of Tumor Biology, Institute of Cancer Research
[4] Oslo University Hospital,Division of Cancer and Genetics, Institute of Medical Genetics
[5] Cardiff University School of Medicine,undefined
来源：
Familial Cancer | 2021年 / 20卷
关键词：
Lynch syndrome; Hereditary non-polyposis colorectal cancer; Colorectal cancer; Colonoscopy; Surveillance; Prevention; Precision medicine; PLSD; Cancer incidence;
D O I：
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学科分类号：
摘要：
The Prospective Lynch Syndrome Database (PLSD) has been developed as an international, multicentre, prospective, observational study that aims to provide age and organ-specific cancer risks according to gene and gender, estimates of survival after cancer and information on the effects of interventions. Recent reports from PLSD provided improved estimates of cancer risks and survival and showed that different time intervals between surveillance colonoscopies did not affect the incidence, stage or prognosis of colorectal cancer. The PLSD reports suggest that current management guidelines for Lynch syndrome should be revised in light of the different gene and gender-specific cancer risks and the good prognosis for the most commonly associated cancers.
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页码：35 / 39
页数：4
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