Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases working party of the European Group for Blood and Marrow Transplantation

被引:0
作者
M Miano
M Labopin
O Hartmann
E Angelucci
J Cornish
E Gluckman
F Locatelli
A Fischer
R M Egeler
R Or
C Peters
J Ortega
P Veys
P Bordigoni
A P Iori
D Niethammer
V Rocha
G Dini
机构
[1] IRCSS Giannina Gaslini,Department of Paediatric Haematology and Oncology
[2] Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (ALWP-EBMT),Department of Paediatric Oncology
[3] Hôpital Saint Antoine AP/HP,Department of Haematology
[4] Bone Marrow Transplantation Unit,Department of Haematology
[5] Institut Gustave Roussy,Department of Paediatric Oncology and Bone Marrow Transplantation
[6] Pesaro Hospital,Department of Haematology and Bone Marrow Transplantation
[7] Ospedale A. Businco,Department of Paediatric Haematology
[8] Bristol Royal Hospital for Children,Oncology
[9] Hôpital St Louis,Department of Immunology and Haematology
[10] IRCCS Policlinico San Matteo,Department of Paediatrics
[11] Hôpital Necker,Department of Bone Marrow Transplantation
[12] University Hospital,Department of Paediatric Haematology and Oncology
[13] Hadassah Hebrew University Medical Centre,Department of Haematology
[14] BMT Unit,Department of Paediatrics
[15] St Anna Kinderspital,undefined
[16] Hospital Vall d’Hebron,undefined
[17] Bone Marrow Transplantation Unit,undefined
[18] Great Ormond Street Hospital for Children NHS Trust,undefined
[19] Bone Marrow Transplantation Unit,undefined
[20] Hôpital d’Enfants,undefined
[21] Medicine Infantile,undefined
[22] Università La Sapienza,undefined
[23] University Hospital,undefined
[24] Acute Leukaemia Working Party of the European Bone and Marrow Transplant group (ALWP-EBMT),undefined
[25] Hôpital St Louis,undefined
来源
Bone Marrow Transplantation | 2007年 / 39卷
关键词
haematopoietic stem cell transplantation; children; paediatric diseases;
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摘要
This paper describes the trends in haematopoietic stem cell transplantation (HSCT) activity for children in Europe over the last three decades. We analysed 31 713 consecutive paediatric HSCTs reported by the European Group for Blood and Marrow Transplantation (EBMT) centres between 1970 and 2002. Data were taken from the EBMT registry and were compared according to period and centre category (paediatric or combined). Since 1996, there has been a significant increase in the number of HSCTs performed exclusively by paediatric centres, as well as in the number of alternative donor HSCTs, and in the use of peripheral blood stem cells (P<0.0001). The number of allogeneic HSCTs (allo-HSCTs) for acute lymphoblastic leukaemia, acute myeloblastic leukaemia and chronic myeloid leukaemia remained stable, whereas it increased for myelodysplastic syndromes and lymphomas, and decreased significantly for non-malignant diseases (P<0.0001). Multivariate analysis showed that younger age, human leukocyte antigen genoidentical donors, HSCT performed after 1996 and transplant centres performing more than 10 allo-HSCT/year were all associated with decreased transplant-related mortality (TRM) (P<0.0001). The number of autologus HSCTs (auto-HSCTs) for acute leukaemia decreased significantly, whereas it increased for solid tumours (P<0.0001). Multivariate analysis showed that both auto-HSCT performed before 1996 and paediatric solid tumours (P<0.0001) had higher TRM. Indications for paediatric HSCT have changed considerably during the last seven years. These changes provide tools for decision making in health-care planning and counselling.
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页码:89 / 99
页数:10
相关论文
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