Imaging axonal damage in multiple sclerosis by means of MR spectroscopy

被引:14
作者
N. De Stefano
S. Narayanan
M. Mortilla
L. Guidi
M.L. Bartolozzi
A. Federico
D.L. Arnold
机构
[1] Neurometabolic Unit,
[2] Institute of Neurological Sciences,undefined
[3] University of Siena,undefined
[4] Viale Bracci 2,undefined
[5] I-53100 Siena,undefined
[6] Italy,undefined
[7] NMR Center,undefined
[8] University of Siena,undefined
[9] Siena,undefined
[10] Italy,undefined
[11] Department of Neurology and Neurosurgery,undefined
[12] Montreal Neurological Institute,undefined
[13] McGill University,undefined
[14] Montreal,undefined
[15] Quebec,undefined
[16] Canada,undefined
[17] Neurological Unit,undefined
[18] Empoli Hospital,undefined
[19] Florence,undefined
[20] Italy,undefined
关键词
Multiple Sclerosis; Proton Magnetic Resonance; White Matter; Early Treatment; Magnetic Resonance Spectroscopy;
D O I
10.1007/s100720070031
中图分类号
学科分类号
摘要
Axonal damage in multiple sclerosis has become an important issue. This has been emphasized by recent in vivo proton magnetic resonance (MR) spectroscopy and in vitro pathology studies that have found axonal damage in both lesions and the surrounding normal-appearing white matter. In particular, proton MR spectroscopy, by monitoring levels of N-acetylaspartate (a putative marker of axonal integrity), has been particularly illuminating, as the extent of axonal injury associated with white matter inflammation and demyelination had not been well appreciated from classical pathology studies. Recent MR data demonstrate that cerebral axonal damage begins and contributes to disability from the earliest stages of the disease. This implies that the apparently primary role of axonal damage and loss in the pathogenesis of the disease should be given due importance, and argues for the early treatment of multiple sclerosis with agents directed not only against inflammation, but also towards axonal protection.
引用
收藏
页码:S883 / S887
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