The perfect personalized cancer therapy: cancer vaccines against neoantigens

被引：0
作者：
Luigi Aurisicchio
Matteo Pallocca
Gennaro Ciliberto
Fabio Palombo
机构：
[1] Takis,
[2] Biogem,undefined
[3] UOSD SAFU,undefined
[4] IRCSS Regina Elena National Cancer Institute,undefined
[5] Scientific Directorate,undefined
[6] IRCCS Regina Elena National Cancer Institute,undefined
[7] Alleanza contro il Cancro,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 37卷
关键词：
Term Clinical Benefit; Immune Checkpoint Inhibitors (ICI); Fragments Per Kilobase Of Transcript Per Million Mapped (FPKM); Tumor-infiltrating Lymphocytes (TILs); Neoantigen Prediction;
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摘要：
In the advent of Immune Checkpoint inhibitors (ICI) and of CAR-T adoptive T-cells, the new frontier in Oncology is Cancer Immunotherapy because of its ability to provide long term clinical benefit in metastatic disease in several solid and liquid tumor types. It is now clear that ICI acts by unmasking preexisting immune responses as well as by inducing de novo responses against tumor neoantigens. Thanks to theprogress made in genomics technologies and the evolution of bioinformatics, neoantigens represent ideal targets, due to their specific expression in cancer tissue and the potential lack of side effects. In this review, we discuss the promise of preclinical and clinical results with mutation-derived neoantigen cancer vaccines (NCVs) along with the current limitations from bioinformatics prediction to manufacturing an effective new therapeutic approach.
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