Serum levels of S100B, S100A1B and S100BB are all related to outcome after severe traumatic brain injury

被引：0
作者：
K. Nylén
M. Öst
L. Z. Csajbok
I. Nilsson
C. Hall
K. Blennow
B. Nellgård
L. Rosengren
机构：
[1] Sahlgrenska University Hospital,Department of Neurology, Institute of Clinical Neuroscience
[2] University of Göteborg,Neurointensive Care Unit, Department of Anaesthesia
[3] Sahlgrenska University Hospital,Department of Neuroradiology
[4] University of Göteborg,Unit of Experimental Neuroscience, Department of Clinical Neuroscience
[5] Sahlgrenska University Hospital,undefined
[6] University of Göteborg,undefined
[7] Sahlgrenska University Hospital,undefined
[8] University of Göteborg,undefined
[9] Fujirebio Diagnostics AB,undefined
来源：
Acta Neurochirurgica | 2008年 / 150卷
关键词：
Keywords: S100B; S100A1B; S100BB; traumatic brain injury; outcome; biochemical brain damage markers.;
D O I：
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中图分类号：
学科分类号：
摘要：
Objectives. S100B is an established marker of brain damage. Used in the context as a biochemical marker, S100B denotes a measurement of all S100 proteins, including at least one S100B monomer, i.e. the sum of the two dimers S100A1B and S100BB. Almost all published studies are based on this “sum concentration”. However, the brain specificity of S100B has been questioned and increased serum levels have also been reported after trauma without head injury. Since the S100B monomer dominates in the brain, we hypothesised that the S100BB dimer should be better related to outcome after severe traumatic brain injury than S100A1B or the “sum concentration”.
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页码：221 / 227
页数：6
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