Serum levels of S100B, S100A1B and S100BB are all related to outcome after severe traumatic brain injury

被引：0
作者：
K. Nylén
M. Öst
L. Z. Csajbok
I. Nilsson
C. Hall
K. Blennow
B. Nellgård
L. Rosengren
机构：
[1] Sahlgrenska University Hospital,Department of Neurology, Institute of Clinical Neuroscience
[2] University of Göteborg,Neurointensive Care Unit, Department of Anaesthesia
[3] Sahlgrenska University Hospital,Department of Neuroradiology
[4] University of Göteborg,Unit of Experimental Neuroscience, Department of Clinical Neuroscience
[5] Sahlgrenska University Hospital,undefined
[6] University of Göteborg,undefined
[7] Sahlgrenska University Hospital,undefined
[8] University of Göteborg,undefined
[9] Fujirebio Diagnostics AB,undefined
来源：
Acta Neurochirurgica | 2008年 / 150卷
关键词：
Keywords: S100B; S100A1B; S100BB; traumatic brain injury; outcome; biochemical brain damage markers.;
D O I：
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学科分类号：
摘要：
Objectives. S100B is an established marker of brain damage. Used in the context as a biochemical marker, S100B denotes a measurement of all S100 proteins, including at least one S100B monomer, i.e. the sum of the two dimers S100A1B and S100BB. Almost all published studies are based on this “sum concentration”. However, the brain specificity of S100B has been questioned and increased serum levels have also been reported after trauma without head injury. Since the S100B monomer dominates in the brain, we hypothesised that the S100BB dimer should be better related to outcome after severe traumatic brain injury than S100A1B or the “sum concentration”.
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页码：221 / 227
页数：6
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  • [1] Anderson RE(2001)High Serum S100B levels for trauma patients without head injuries Neurosurgery 48 1255-1260
  • [2] Hansson LO(2001)Increase in serum S100A1B and S100BB during cardiac surgery arises from extracerebral sources Ann Thorac Surg 71 1512-1517
  • [3] Nilsson O(2003)Biochemical markers of cerebrospinal ischemia after repair of aneurysms of the descending and thoracoabdominal aorta J Cardiothorac Vasc Anesth 17 598-603
  • [4] Dijlai-Merzoug R(1983)A rapid separation of the S100 subunits by high performance liquid chromatography: the subunit compositions of S100 proteins Biochem Int 6 419-426
  • [5] Settergren G(1985)Characterization of human brain S100 protein fraction: amino acid sequence of s100beta J Neurochem 45 700-705
  • [6] Anderson RE(2003)Serum S100beta: a noninvasive marker of blood-brain barrier function and brain lesions Cancer 97 2806-2813
  • [7] Hansson LO(2002)Serum S-100beta as a possible marker of blood-brain barrier disruption Brain Res 940 102-104
  • [8] Nilsson O(1991)A new classification of head injury based on computerized tomography J Neurosurg 75 S14-S20
  • [9] Liska J(2004)S100 in mild traumatic brain injury Brain Inj 18 671-683
  • [10] Settergren G(2006)Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome J Neurolog Sci 240 85-91
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