Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients

被引:0
作者
Mohammed Al-Jumaan
Hoyin Chu
Abdullah Alsulaiman
Sabrina Y. Camp
Seunghun Han
Riaz Gillani
Yousef Al Marzooq
Fatmah Almulhim
Chittibabu Vatte
Areej Al Nemer
Afnan Almuhanna
Eliezer M. Van Allen
Amein Al-Ali
Saud H. AlDubayan
机构
[1] Imam Abdulrahman bin Faisal University,College of Medicine
[2] Dana-Farber Cancer Institute,Department of Medical Oncology
[3] Harvard Medical School,Cancer Program
[4] The Broad Institute of MIT and Harvard,Department of Pediatric Oncology
[5] Harvard Medical School,Department of Pediatrics
[6] Dana-Farber Cancer Institute,Center for Cancer Genomics
[7] Harvard Medical School,Division of Genetics
[8] Boston Children’s Hospital,College of Medicine
[9] Dana-Farber Cancer Institute,undefined
[10] Brigham and Women’s Hospital,undefined
[11] King Saud bin Abdulaziz University for Health Sciences,undefined
来源
Genome Medicine | / 15卷
关键词
Low-pass whole genome sequencing; Imputation; Polygenic risk score; Breast cancer; Arab population; Age of onset; Pathogenic variants;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 181 条
[1]  
Buniello A(2019)The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 Nucleic Acids Res. 47 D1005-12
[2]  
MacArthur JAL(2020)The mutational constraint spectrum quantified from variation in 141,456 humans Nature. 581 434-43
[3]  
Cerezo M(2020)Genetic variation in the Middle East-an opportunity to advance the human genetics field Genome Med. 12 116-6
[4]  
Harris LW(2016)Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery Nat Genet. 48 1071-8
[5]  
Hayhurst J(2018)Burden of breast cancer in the Arab world: findings from Global Burden of Disease, 2016 J Epidemiol Glob Health. 8 54-52
[6]  
Malangone C(2010)Age at diagnosis of breast cancer in Arab nations Int J Surg. 8 448-52
[7]  
Karczewski KJ(2019)Worldwide age at onset of female breast cancer: a 25-year population-based cancer registry study Sci Rep. 9 14111-91
[8]  
Francioli LC(2022)Genetic predisposition to cancer across people of different ancestries in Qatar: a population-based, cohort study Lancet Oncol. 23 341-68
[9]  
Tiao G(2019)Analysis of polygenic risk score usage and performance in diverse human populations Nat Commun. 10 3328-37
[10]  
Cummings BB(2019)Clinical use of current polygenic risk scores may exacerbate health disparities Nat Genet. 51 584-7