Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia harboring trisomy 8

被引：0
作者：
Takaaki Konuma
Tadakazu Kondo
Takuya Yamashita
Naoyuki Uchida
Takahiro Fukuda
Yukiyasu Ozawa
Kazuteru Ohashi
Hiroyasu Ogawa
Chiaki Kato
Satoshi Takahashi
Heiwa Kanamori
Tetsuya Eto
Chiaki Nakaseko
Akio Kohno
Tatsuo Ichinohe
Yoshiko Atsuta
Akiyoshi Takami
Shingo Yano
机构：
[1] The University of Tokyo,Department of Hematology/Oncology, The Institute of Medical Science
[2] Kyoto University,Department of Hematology and Oncology, Graduate School of Medicine
[3] St Luke’s International University and Hospital,Department of Hematology and Oncology
[4] Toranomon Hospital,Department of Hematology
[5] National Cancer Center Hospital,Department of Hematopoietic Stem Cell Transplantation Division
[6] Japanese Red Cross Nagoya First Hospital,Department of Hematology
[7] Komagome Hospital,Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center
[8] Hyogo College of Medicine,Division of Hematology, Department of Internal Medicine
[9] Meitetsu Hospital,Department of Hematology
[10] The University of Tokyo,Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science
[11] Kanagawa Cancer Center,Department of Hematology
[12] Hamanomachi Hospital,Department of Hematology
[13] Chiba University Hospital,Department of Hematology
[14] JA Aichi Konan Kosei Hospital,Department of Hematology and Oncology
[15] Hiroshima University,Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine
[16] Japanese Data Center for Hematopoietic Cell Transplantation,Department of Healthcare Administration
[17] Nagoya University Graduate School of Medicine,Division of Hematology, Department of Internal Medicine
[18] Aichi Medical University School of Medicine,Division of Clinical Oncology and Hematology, Department of Internal Medicine
[19] Jikei University School of Medicine,undefined
来源：
Annals of Hematology | 2017年 / 96卷
关键词：
Trisomy 8; Acute myeloid leukemia; Allogeneic hematopoietic stem cell transplantation; Cytogenetics; Additional abnormality;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Trisomy 8 (+8) is one of the most common cytogenetic abnormalities in adult patients with acute myeloid leukemia (AML). However, the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients with AML harboring +8 remains unclear. To evaluate, the outcome and prognostic factors in patients with AML harboring +8 as the only chromosomal abnormality or in association with other abnormalities, we retrospectively analyzed the Japanese registration data of 631 adult patients with AML harboring +8 treated with allogeneic HSCT between 1990 and 2013. In total, 388 (61%) patients were not in remission at the time of HSCT. With a median follow-up of 38.5 months, the probability of overall survival and the cumulative incidence of relapse at 3 years were 40 and 34%, respectively. In the multivariate analysis, two or more additional cytogenetic abnormalities and not being in remission at the time of HSCT were significantly associated with a higher overall mortality and relapse. Nevertheless, no significant impact on the outcome was observed in cases with one cytogenetic abnormality in addition to +8. Although more than 60% of the patients received HSCT when not in remission, allogeneic HSCT offered a curative option for adult patients with AML harboring +8.
引用
收藏
页码：469 / 478
页数：9
相关论文
共 170 条
  • [1] Slovak ML(2000)Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a southwest oncology group/eastern cooperative oncology group study Blood 96 4075-4083
  • [2] Kopecky KJ(2002)Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from cancer and leukemia group B (CALGB 8461) Blood 100 4325-4336
  • [3] Cassileth PA(2010)Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials Blood 116 354-365
  • [4] Harrington DH(2010)Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet Blood 115 453-474
  • [5] Theil KS(2002)The value of allogeneic bone marrow transplant in patients with acute myeloid leukaemia at differing risk of relapse: results of the UK MRC AML 10 trial Br J Haematol 118 385-400
  • [6] Mohamed A(2005)Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission Cancer 103 1652-1658
  • [7] Byrd JC(2007)Impact of cytogenetics on outcome of matched unrelated donor hematopoietic stem cell transplantation for acute myeloid leukemia in first or second complete remission Blood 110 409-417
  • [8] Mrózek K(2007)Impact of cytogenetics on outcome of de novo and therapy-related AML and MDS after allogeneic transplantation Biology of Blood and Marrow Transplantation 13 655-664
  • [9] Dodge RK(2012)Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a Center for International Blood and Marrow Transplant Research study Biology of Blood and Marrow Transplantation 18 280-288
  • [10] Carroll AJ(2009)Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT Bone Marrow Transplant 44 589-594
12345678910