Multiple types of logic gates based on a single G-quadruplex DNA strand

被引：0
作者：
Yahui Guo
Lu Zhou
Lijun Xu
Xiaodong Zhou
Jiming Hu
Renjun Pei
机构：
[1] Key Laboratory of Nano-Bio Interface,
[2] Division of Nanobiomedicine,undefined
[3] Collaborative Innovation Center of Suzhou Nano Science and Technology,undefined
[4] Suzhou Institute of Nano-Tech and Nano-Bionics,undefined
[5] Chinese Academy of Sciences,undefined
[6] Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education),undefined
[7] College of Chemistry & Molecular Sciences,undefined
[8] Wuhan University,undefined
来源：
Scientific Reports | / 4卷
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摘要：
In this work, we demonstrate the use of a single DNA strand and G-quadruplex-specific dye NMM as a label-free switch for the construction of series of basic logic gates (YES, NOT, OR, INHIBIT, NOR, AND). The simple GT-rich sequence could be used to interact with several molecules (K+, thrombin, Hg2+ and Pb2+) to form different structures that can be distinguished by the label-free dye NMM. Our study showed that a single G-qudruplex DNA strand can function as multiple types of one-input and two-input logic gates with different combinations of input molecules.
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