Stereotactic radiosurgery for brain metastases from hepatocellular carcinoma

被引:0
作者
Jung Ho Han
Dong Gyu Kim
Hyun-Tai Chung
Sun Ha Paek
Chul-Kee Park
Chae-Yong Kim
Young-Hoon Kim
Hee-Won Jung
机构
[1] Seoul National University Bundang Hospital,Department of Neurosurgery
[2] Seoul National University Hospital,Department of Neurosurgery
[3] Seoul National University College of Medicine,Department of Neurosurgery
来源
Journal of Neuro-Oncology | 2013年 / 115卷
关键词
Stereotactic radiosurgery; Hepatocellular carcinoma; Brain metastases; Stereotactic radiotherapy;
D O I
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学科分类号
摘要
The purpose of this study is to investigate the possible role of stereotactic radiosurgery (SRS) in the management of patients with brain metastases from hepatocellular carcinoma (HCC). Thirty-two consecutive patients with 80 brain metastases from HCC were treated with SRS. Twenty-eight (87.5 %) patients were male, and the mean age of the patients was 54 ± 12 years (range 22–73). Twenty-seven (84.4 %) patients were classified as RTOG RPA Class 2. The mean tumor volume was 6.14 ± 11.3 cm3 (range 0.01–67.3). The mean marginal dose prescribed was 20.1 ± 3.6 Gy (range 10.0–25.0). The median overall survival time after SRS was 11.3 ± 5.8 weeks (95 % CI 0–22.7). A greater total volume of brain metastases (>14 cm3) was the only independent prognostic factor (HR = 2.419; 95 % CI 1.040–5.624; p = 0.040). The actuarial control rate of brain metastases was 51.3 % at 4 months after SRS. The prescribed marginal dose (>18 Gy) was significantly related with the actuarial tumor control (HR = 0.254; 95 % CI 0.089–0.725; p = 0.010). The prognosis of patients with brain metastases from HCC is dismal even with the modern technology of radiosurgery. The marginal dose prescribed should be reevaluated to improve upon the current poor local control rates.
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页码:45 / 51
页数:6
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