Nasal Priming with Lactobacillus rhamnosus CRL1505 Stimulates Mononuclear Phagocytes of Immunocompromised Malnourished Mice: Improvement of Respiratory Immune Response

被引:0
作者
Natalia Barbieri
Susana Salva
Matías Herrera
Julio Villena
Susana Alvarez
机构
[1] Centro de Referencia para Lactobacilos (CERELA-CONICET),Laboratorio de Inmunobiotecnología
[2] Universidad Nacional de Chilecito (UNdeC),Departamento de Ciencias Básicas y Tecnológicas
[3] CONICET,Instituto de Bioquímica Aplicada, Facultad de Bioquímica, Química y Farmacia
[4] Planta Piloto de Procesos Industriales Microbiológicos (PROIMI-CONICET),undefined
[5] Universidad Nacional de Tucumán,undefined
来源
Probiotics and Antimicrobial Proteins | 2020年 / 12卷
关键词
Macrophages; Dendritic cells; Pneumococcal infection; Immunocompromised hosts;
D O I
暂无
中图分类号
学科分类号
摘要
The effect of Lactobacillus rhamnosus CRL1505 (Lr) on macrophages (Ma) and dendritic cells (DC) in the orchestration of anti-pneumococcal immunity was studied using malnutrition and pneumococcal infection mouse models. Monocytes (Mo), Ma, and DC in two groups of malnourished mice fed with balanced diet (BCD) were studied through flow cytometry; one group was nasally administered with Lr (BCD+Lr group), and the other group was not (BCD group). Well-nourished (WNC) and malnourished (MNC) mice were used as controls.
引用
收藏
页码:494 / 504
页数:10
相关论文
共 184 条
[1]  
Cortez-Retamozo V(2012)Regulation of macrophage and dendritic cell responses by their lineage precursors J Innate Immun 4 411-423
[2]  
Etzrodt M(2010)Development of monocytes, macrophages, and dendritic cells Science 327 656-661
[3]  
Pittet MJ(2007)Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages J Immunol 179 3488-3494
[4]  
Geissmann F(2012)Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses Am J Respir Cell Mol Biol 46 165-172
[5]  
Manz MG(2005)Structure and function of the spleen Nat Rev Immunol 5 606-616
[6]  
Jung S(2007)Monocytes give rise to mucosal, but not splenic, conventional dendritic cells J Exp Med 204 171-180
[7]  
Sieweke MH(2010)Unravelling mononuclear phagocyte heterogeneity Nat Rev Immunol 10 453-460
[8]  
Merad M(2011)Malnutrition and gastrointestinal and respiratory infections in children: a public health problem Int J Environ Res Public Health 8 1174-1205
[9]  
Ley K(2014)Probiotics and lung immune responses Ann Am Thorac Soc 11 S33-S37
[10]  
Landsman L(2014)Probiotics in respiratory virus infections Eur J Clin Microbiol Infect Dis 33 1289-1302