Layer-specific systolic and diastolic strain in hypertensive patients with and without mild diastolic dysfunction

被引：9

作者：

Sharif H. ^{[1
,2
]}

Ting S. ^{[3
,4
,5
]}

Forsythe L. ^{[6
]}

McGregor G. ^{[7
]}

Banerjee P. ^{[8
]}

O’Leary D. ^{[2
,9
]}

Ditor D. ^{[1
,9
]}

George K. ^{[6
]}

Zehnder D. ^{[3
,10
]}

Oxborough D. ^{[6
]}

机构：

[1] Department of Kinesiology, Brock University, St Catharines, ON

[2] Health Sciences, Brock University, St Catharines, ON

[3] Division of Nephrology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry

[4] Division of Metabolic and Vascular Health, University of Warwick, Coventry

[5] Department of Acute Medicine, Heart of England NHS Foundation Trust, Birmingham

[6] Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool

[7] Centre for Applied Biological and Exercise Sciences, Coventry University

[8] Department of Cardiology, University Hospitals Coventry and Warwickshire, Coventry

[9] Brock-Niagara Centre for Health and Well-Being, Brock University, St Catharines, ON

[10] Department of Acute Medicine, North Cumbria University Hospital NHS Trust, Carlisle

来源：

Echo Research & Practice | 2018年 / 5卷 / 1期

关键词：

F diastolic dysfunction f hypertension f layer-specific strain f transmural gradient;

D O I：

10.1530/ERP-17-0072

中图分类号：

学科分类号：

摘要：

This study sought to examine layer-specific longitudinal and circumferential systolic and diastolic strain, strain rate (SR) and diastolic time intervals in hypertensive patients with and without diastolic dysfunction. Fifty-eight treated hypertensive patients were assigned to normal diastolic function (NDF, N=39) or mild diastolic dysfunction (DD, N=19) group. Layer-specific systolic and diastolic longitudinal and circumferential strains and SR were assessed. Results showed no between-group difference in left ventricular mass index (DD: 92.1±18.1 vs NDF: 88.4±16.3; P=0.44). Patients with DD had a proportional reduction in longitudinal strain across the myocardium (endocardial for DD −13±4%; vs NDF −17±3, P<0.01; epicardial for DD −10±3% vs NDF −13±3%, P<0.01; global for DD: −12±3% vs NDF: −15±3, P=0.01), and longitudinal mechanical diastolic impairments as evidenced by reduced longitudinal strain rate of early diastole (DD 0.7±0.2L/s vs NDF 1.0±0.3L/s, P<0.01) and absence of a transmural gradient in the duration of diastolic strain (DD endocardial: 547±105ms vs epicardial: 542±113ms, P=0.24; NDF endocardial: 566±86ms vs epicardial: 553±77ms, P=0.03). Patients with DD also demonstrate a longer duration of early circumferential diastolic strain (231±71ms vs 189±58ms, P=0.02). In conclusion, hypertensive patients with mild DD demonstrate a proportional reduction in longitudinal strain across the myocardium, as well as longitudinal mechanical diastolic impairment, and prolonging duration of circumferential mechanical relaxation. © 2018 The authors Published by Bioscientifica Ltd

引用

页码：41 / 49

页数：8

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