An update on the hepatitis e virus

被引：15
作者：
Sclair S.N. [1 ,2 ]
Schiff E.R. [1 ,2 ]
机构：
[1] Department of Medicine, Division of Hepatology, University of Miami Miller School of Medicine, Miami, FL
[2] Schiff Center for Liver Diseases, Jackson Medical Towers, Miami, FL 33136
来源：
Current Gastroenterology Reports | 2013年 / 15卷 / 2期
关键词：
Chronic liver disease; Cirrhosis; DILI; Hepatitis; Hepatitis E; Pregnancy; Ribavirin; Transplantation; Vaccine; Zoonosis;
D O I：
10.1007/s11894-012-0304-2
中图分类号：
学科分类号：
摘要：
There have been recent key advances in the understanding of hepatitis E virus infection. Since the early 1980s, when the virus was first discovered, hepatitis E has been described as a disease that is endemic only in the African and Asian subcontinents, a disease that is transmitted via the fecal-oral route, and a disease that causes an acute illness that typically resolves, with the exception of the third trimester of pregnancy, when infection can be deadly. We now know that genotype 3 is likely a porcine zoonotic disease that is quite prevalent in certain industrialized nations. Hepatitis E carries high morbidity and mortality in patients with underlying liver disease and can become a chronic infection that causes fibrosis in immunocompromised hosts. Lastly, two vaccines have been developed and studied in clinical trials, with excellent results. © 2013 Springer Science+Business Media New York.
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