Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis

被引：0

作者：

Dimitrios E. Magouliotis

Vasiliki S. Tasiopoulou

Alexis A. Svokos

Konstantina A. Svokos

Christina Chatedaki

Eleni Sioka

Dimitris Zacharoulis

机构：

[1] University Hospital of Larissa,Department of Surgery

[2] University of Thessaly Viopolis Larissa Greece,Faculty of Medicine, School of Health Sciences

[3] Riverside Regional Medical Center,Department of Microbiology

[4] The Warren Alpert Medical School of Brown University,undefined

[5] University Hospital of Larissa,undefined

来源：

Obesity Surgery | 2017年 / 27卷

关键词：

Ursodeoxycholic acid; Gallstone; Bariatric surgery; Meta-analysis; Gallstone prevention;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We aim to review the available literature on obese patients treated with ursodeoxycholic acid (UDCA) in order to prevent gallstone formation after bariatric surgery. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 1355 patients. Random-effects meta-analysis showed a lower incidence of gallstone formation in patients taking UDCA. Subgroup analysis reported fewer cases of gallstone disease in the UDCA group in relation to different bariatric procedures, doses of administered UDCA, and time from bariatric surgery. Adverse events were similar in both groups. Fewer patients required cholecystectomy in UDCA group. No deaths were reported. The administration of UDCA after bariatric surgery seems to prevent gallstone formation.

引用

页码：3021 / 3030

页数：9

共 80 条

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