Morita Baylis Hillman Adduct Serves as Ligand in the Synthesis of Transition Metal Complexes Exhibiting Antibacterial Activity

被引:0
作者
Shazia Ishfaq
Hamid Ullah
Taj Ur Rahman
Sadia Majid
Nisar Ahmad
Mujtaba Ellahi
Syed Badshah
Muhammad Akram
Noornama Panezai
机构
[1] Mohi-ud-Din Islamic University,Department of Chemistry
[2] FBS,Department of Chemistry
[3] BUITEMS,Department of Physics
[4] FBS,Institute of Chemical Sciences
[5] BUITEMS,Department of Chemistry
[6] Gomal University,undefined
[7] PCSIR Laboratories Complex,undefined
[8] University of Karachi,undefined
来源
Pharmaceutical Chemistry Journal | 2022年 / 56卷
关键词
MBH adduct; transition metal complexes; antibacterial activity;
D O I
暂无
中图分类号
学科分类号
摘要
In the present work, Morita—Baylis–Hillman (MBH) adduct ligand 3 was prepared under MBH reaction conditions. The compound was purified by chromatographic techniques and structurally confirmed by methods of spectral analysis. Ligand 3 was separately treated with various salts of transition metals (Mn, Cu, Ce and Lu) under basic conditions with and reflux and stirring. This treatment yielded complexes 5–8, the molecular and structural formulas of which were established by spectral and elemental analysis. Then, complexes 5–8 were checked for their antibacterial potential against four strains (E. coli, S. aureus, P. mirabilis, and P. aeruginosa). Almost all compounds exhibited good activity except Mn and Lu complexes which were inactive against S. aureus and P. aeruginosa, respectively. Cerium complex showed moderate antibacterial activity against all selected strains. Among all, Cu complex was fund to be the most active one against the selected bacterial strains. This study demonstrated the first example of using the MBH adduct as ligand for the formation of complexes.
引用
收藏
页码:906 / 912
页数:6
相关论文
共 97 条
  • [1] Paioti PH(2011)undefined Tetrahedron Lett. 52 6180-6184
  • [2] Coelho F(2004)undefined Tetrahedron Lett. 45 3561-3564
  • [3] Reddy SR(2012)undefined J. Org. Chem. 77 10353-10361
  • [4] Das ST(2014)undefined Curr. Org. Chem. 18 3078-3119
  • [5] Punniyamurthy T(2010)undefined Tetrahedron 66 9875-9879
  • [6] Zheng Y(2017)undefined ACS Catalysis 8 742-746
  • [7] Li X(2015)undefined Int. Technol. Innov. Res. J. 1 1-8
  • [8] Ren C(2018)undefined J. Org. Chem. 83 2660-2675
  • [9] Bhowmik S(2010)undefined Tetrahedron 66 4370-4376
  • [10] Batra S(2018)undefined Bioorg. Chem. 78 24-28