Synthesis of 2-substituted cinchoninic acid amides and their cyclization into 1,2,4-triazolo[4,3-a]-quinoline-9- and 1,2,4-triazino[4,3-a]quinoline-10-carboxylic acid amides

被引：0
|
作者：
Mikhalev A.I. [1 ]
Kon'shin M.E. [1 ]
Vakhrin M.I. [1 ]
机构：
[1] Perm Pharmaceutical Academy
来源：
Chemistry of Heterocyclic Compounds | 1997年 / 33卷 / 5期
关键词：
Ester; Ethyl; Organic Chemistry; Amide; Aldehyde;
D O I：
10.1007/BF02291948
中图分类号：
学科分类号：
摘要：
Substituted amides of 2-hydrazino- and 2-ethylhydrazinocinchoninic acids react with pyruvic acid and its ethyl ester to give amides of 3-methyl-4-oxo-1,2,4-triazino[4,3-a]quinoline-10-carboxylic acid. On reaction with aromatic aldehydes they are converted into amides of 2-ethyl-3-phenyl-2,3-dihydro-1,2,4-triazolo[4,3-a]quinoline-9-carboxylic acid, or, in the case of unsubstituted hydrazines, into amides of 2-arylidenehydrazinocinchoninic acid, which was oxidized to substituted 1,2,4-triazolo[4,3-a]quinolines. ©1997 Plenum Publishing Corporation.
引用
收藏
页码：609 / 613
页数：4
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