The synthesis of 2α,3α-isopropylidenedioxy-6,6-ethylenedioxy-5α-androst-15-en-17-one and its 2β,3β-isomer

被引：0
作者：
R. P. Litvinovskaya
A. V. Baranovsky
M. A. Averkova
V. A. Khripach
机构：
[1] National Academy of Sciences of Belarus,Institute of Bioorganic Chemistry
来源：
Russian Journal of Bioorganic Chemistry | 2007年 / 33卷
关键词：
androstane and Δ; -androstane analogues; brassinosteroids; synthesis;
D O I：
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学科分类号：
摘要：
Androstane and Δ15-androstane analogues of brassinosteroids were synthesized from dehydroepiandrosterone. The key stage, hydroxylation of 17β-acetoxyandrost-2-en-6-one double bond with OsO4, yielded the corresponding 2α,3α-and 2β,3β-diols. The target 2α,3α-isopropylidenedioxy-6,6-ethylenedioxy-5α-androst-15-en-17-one and its 2β,3β-isomer were obtained by dehydrosilylation of the corresponding silylenol ethers with palladium acetate.
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页码：320 / 325
页数：5
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