Developments of 3D polycaprolactone/beta-tricalcium phosphate/collagen scaffolds for hard tissue engineering

被引：0

作者：

Mehmet O. Aydogdu

Bilcen Mutlu

Mustafa Kurt

Ahmet T. Inan

Serap E. Kuruca

Gökçe Erdemir

Yesim M. Sahin

Nazmi Ekren

Faik N. Oktar

Oguzhan Gunduz

机构：

[1] Marmara University,Center for Nanotechnology & Biomaterials Research

[2] Marmara University,Department of Metallurgical and Materials Engineering, Master of Science, Institute of Pure and Applied Sciences

[3] Marmara University,Department of Mechanical Engineering, Faculty of Engineering

[4] Istanbul University,Department of Physiology

[5] Istanbul University,Department of Molecular Medicine, The Institute of Experimental Medicine

[6] Istanbul Arel University,Department of Biomedical Engineering

[7] Marmara University,Department of Electrical and Electronics Engineering, Faculty of Technology

[8] Marmara University,Department of Bioengineering, Faculty of Engineering

[9] Marmara University,Department of Metallurgical and Materials Engineering, Faculty of Technology

来源：

Journal of the Australian Ceramic Society | 2019年 / 55卷

关键词：

Biomaterials; Biomedical engineering; Additive manufacturing; Hard tissue scaffolds;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (β-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the β-TCP concentration using 3D bioprinting method. Computer-aided drawing was applied in order to digitally design the scaffolds while instead of solid filaments, materials were prepared as a blend solution and controlled evaporation of the solvent during the bioprinting was enabled the proper solidification of the scaffolds, and they were successfully produced with well-defined porous structure. This work demonstrated the feasibility of complex PCL/β-TCP/collagen scaffolds as an alternative in the 3D bioprinting engineering to the fabrication of porous scaffolds for tissue engineering.

引用

页码：849 / 855

页数：6