Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors

被引:0
作者
J S L Kloth
A Pagani
M C Verboom
A Malovini
C Napolitano
W H J Kruit
S Sleijfer
N Steeghs
A Zambelli
R H J Mathijssen
机构
[1] Erasmus MC Cancer Institute,Department of Medical Oncology
[2] Fondazione S. Maugeri,Department of Medical Oncology
[3] Leiden University Medical Centre,Department of Clinical Oncology
[4] Laboratory of Informatics and Systems Engineering for Clinical Research,Department of Molecular Cardiology
[5] Salvatore Maugeri Research and Care Institute,Department of Medical Oncology
[6] IRCCS Fondazione S. Maugeri,Department of Medical Oncology
[7] Cancer Genomics Netherlands,undefined
[8] Netherlands Cancer Institute,undefined
[9] Ospedale Papa Giovanni XXIII,undefined
来源
British Journal of Cancer | 2015年 / 112卷
关键词
tyrosine kinase inhibitors; QTc interval; arrhythmia; ECG;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1011 / 1016
页数:5
相关论文
共 149 条
[1]  
Bello CL(2009)Electrocardiographic characterization of the QTc interval in patients with advanced solid tumors: pharmacokinetic- pharmacodynamic evaluation of sunitinib Clin Cancer Res 15 7045-7052
[2]  
Mulay M(2005)Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey Eur J Cardiovasc Prev Rehabil 12 363-368
[3]  
Huang X(2008)Drug-induced QTc interval prolongation: a proposal towards an efficient and safe anticancer drug development Eur J Cancer 44 494-500
[4]  
Patyna S(2008)QTc prolongation and/or oncology drug development: who's in danger? Eur J Cancer 44 486-487
[5]  
Dinolfo M(2012)Evaluation of cardiac safety of lapatinib therapy for ErbB2-positive metastatic breast cancer: a single center experience Med Oncol 29 3232-3239
[6]  
Levine S(2013)Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes Toxicol Appl Pharmacol 272 245-255
[7]  
Van Vugt A(2013)Blocking of the human ether-a-go-go-related gene channel by imatinib mesylate Biol Pharm Bull 36 268-275
[8]  
Toh M(2003)Torsade de pointes Curr Opin Cardiol 18 6-13
[9]  
Baum C(2009)Cardiac ion channels Circ Arrhythm Electrophysiol 2 185-194
[10]  
Rosen L(2013)A randomized, double-blind, placebo-controlled study to evaluate the effect of repeated oral doses of pazopanib on cardiac conduction in patients with solid tumors Cancer Chemother Pharmacol 71 565-573