Potential Role of Muscarinic Agonists in Alzheimer’s Disease

被引：0
作者：
Eleanor E. Avery
Laura D. Baker
Sanjay Asthana
机构：
[1] American Lake Division,Geriatric Research, Education and Clinical Center (GRECC) (182 B), Veterans Affairs Puget Sound Healthcare System
[2] University of Washington School of Medicine,undefined
来源：
Drugs & Aging | 1997年 / 11卷
关键词：
Alzheimer Disease; Muscarinic Receptor; Tacrine; Physostigmine; Muscarinic Acetylcholine Receptor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alzheimer’s disease (AD) is a common neurodegenerative disorder and a leading cause of death among the elderly. Recent advances in our understanding of the neurobiology of AD have provided scientific groundwork for the development of potentially more effective and less toxic treatment strategies for the disease.
引用
收藏
页码：450 / 459
页数：9
相关论文
共 224 条
[71]  
Coyle J.T.(1996)SB 202026, a functionally M Eur J Pharmacol 308 13-6
[72]  
Nelson R.(1995) selective partial agonist alters processing of amyloid precursor protein at the cell surface [abstract] J Chromatography 669 397-83
[73]  
Friedman D.(1994)Safety, tolerability, and pharmacokinetics of SB 202026 in man [abstract] J Pharmacol Exp Ther 269 271-80
[74]  
O’Neill J.(1994)Comparison of the effects of selective and nonselective muscarinic agonists on cognition and thermoregulation in primates J Pharmacol Exp Ther 269 282-4
[75]  
Routtenberg A.(1995)AF150(S): a new functionally selective M J Clin Pharmacol 35 800-35
[76]  
Davis R.(1994) agonist improves cognitive performance in rats Eur J Drug Metab Pharmacokinet 19 179-91
[77]  
Doyle P.(1996)Modulation of rhythmical slow activity, long-term potentiation and memory by muscarinic receptor agonists Soc Neurosci Abstr 22 2154-70
[78]  
Carroll R.(1990)High-performance liquid chromatographic assay for xanomeline, a specific M-1 agonist, and its metabolite in human plasma Neurology 40 175-32
[79]  
Cutler N.(1990)Xanomeline: a novel muscarinic receptor agonist with functional activity for M Neurology 40 1350-204
[80]  
Sramek J.(1989) receptors J Pharmacol Exp Ther 248 825-7
3456789101112