Potential Role of Muscarinic Agonists in Alzheimer’s Disease

被引:0
作者
Eleanor E. Avery
Laura D. Baker
Sanjay Asthana
机构
[1] American Lake Division,Geriatric Research, Education and Clinical Center (GRECC) (182 B), Veterans Affairs Puget Sound Healthcare System
[2] University of Washington School of Medicine,undefined
来源
Drugs & Aging | 1997年 / 11卷
关键词
Alzheimer Disease; Muscarinic Receptor; Tacrine; Physostigmine; Muscarinic Acetylcholine Receptor;
D O I
暂无
中图分类号
学科分类号
摘要
Alzheimer’s disease (AD) is a common neurodegenerative disorder and a leading cause of death among the elderly. Recent advances in our understanding of the neurobiology of AD have provided scientific groundwork for the development of potentially more effective and less toxic treatment strategies for the disease.
引用
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页码:450 / 459
页数:9
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  • [1] Rice D.P.(1993)The economic burden of Alzheimer’s disease care Health Aff 12 164-76
  • [2] Fox P.J.(1997)Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer’s disease Arch Neurol 54 465-73
  • [3] Max W.(1994)A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer’s disease JAMA 271 985-91
  • [4] Bodick N.(1996)Neuropsychiatric aspects of Alzheimer’s disease: the cholinergic hypothesis revisited Neurology 47 876-83
  • [5] Offen W.(1982)The cholinergic hypothesis of geriatric memory dysfunction Science 217 408-17
  • [6] Levey A.(1995)The pharmacology of Alzheimer’s disease based on the cholinergic hypothesis: an update Neurodegeneration 4 349-56
  • [7] Knapp M.(1996)Neurotransmitters, signal transduction and second-messengers in Alzheimer’s disease Acta Neurol Scand 93 25-32
  • [8] Knopman D.(1981)Alzheimer’s disease: evidence for selective loss of cholinergic neurons in nucleus basalis J Neuropathol Exp Neurol 10 122-6
  • [9] Solomon P.(1985)Development of cholinergic drugs for the treatment of Alzheimer’s disease Drug Dev Res 5 77-96
  • [10] Cummings J.L.(1994)Muscarinic receptors and novel strategies for the treatment of age-related brain disorders Life Sci 55 2135-45