An Allele-Specific Polymerase Chain Reaction Method for the Determination of the D85Y Polymorphism in the Human UDPGlucuronosyltransferase 2B15 Gene in a Case-Control Study of Prostate Cancer

被引：0
作者：
Stewart L. MacLeod
Susan Nowell
Jason Plaxco
Nicholas P. Lang
机构：
[1] University of Arkansas for Medical Sciences,Department of Surgery
[2] Central Arkansas Veterans Healthcare System,undefined
来源：
Annals of Surgical Oncology | 2000年 / 7卷
关键词：
Prostate cancer; UDP-glucuronosyltransferase; UGT2B15; Androgen metabolism. UDP-glucuronosyltransferases (EC 2.4.1.17) (UGTs);
D O I：
暂无
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学科分类号：
摘要：
Background: UDP-glucuronosyltransferase 2B15 (UGT2B15) catalyzes the inactivation of dihydrotestosterone (DHT) by forming the DHT-glucuronide and is expressed in normal and hyperplastic prostate tissue. Alterations in the activity of this enzyme could be a major contributing factor to the bioavailability of androgens in target tissue such as the prostate.
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页码：777 / 782
页数：5
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