An Allele-Specific Polymerase Chain Reaction Method for the Determination of the D85Y Polymorphism in the Human UDPGlucuronosyltransferase 2B15 Gene in a Case-Control Study of Prostate Cancer

被引：0
作者：
Stewart L. MacLeod
Susan Nowell
Jason Plaxco
Nicholas P. Lang
机构：
[1] University of Arkansas for Medical Sciences,Department of Surgery
[2] Central Arkansas Veterans Healthcare System,undefined
来源：
Annals of Surgical Oncology | 2000年 / 7卷
关键词：
Prostate cancer; UDP-glucuronosyltransferase; UGT2B15; Androgen metabolism. UDP-glucuronosyltransferases (EC 2.4.1.17) (UGTs);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: UDP-glucuronosyltransferase 2B15 (UGT2B15) catalyzes the inactivation of dihydrotestosterone (DHT) by forming the DHT-glucuronide and is expressed in normal and hyperplastic prostate tissue. Alterations in the activity of this enzyme could be a major contributing factor to the bioavailability of androgens in target tissue such as the prostate.
引用
收藏
页码：777 / 782
页数：5
相关论文
共 132 条
  • [1] Levesque E(1997)Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene Pharmacogenetics 7 317-325
  • [2] Beaulieu M(1991)The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence DNA Cell Biol 10 487-494
  • [3] Green MD(1997)The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence Pharmacogenetics 7 255-269
  • [4] Tephly TR(1998)Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium Mol Pharmacol 54 647-654
  • [5] Belanger A(1991)Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat) J Biol Chem 266 24048-24052
  • [6] Hum DW(1994)Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13 Genomics 23 496-499
  • [7] Burchell B(1992)A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini J Biol Chem 267 3257-3261
  • [8] Nebert DW(1991)Distribution of UDP-glucuronosyltransferase and its endogenous substrate uridine 5’- diphosphoglucuronic acid in human tissues Eur J Clin Pharmacol 41 345-350
  • [9] Nelson DR(1990)Metabolism of drugs and other xenobiotics in the gut lumen and wall Pharmacol Ther 46 67-93
  • [10] Mackenzie PI(1992)Glucuronidation and its role in regulation of biological activity of drugs Annu Rev Pharmacol Toxicol 32 25-49
12345678910