Mystery Unfolding: The Curious Case of Histone H3 Clipping

被引：0
|
作者：
Azad, Gajendra Kumar [1 ]
机构：
[1] Patna Univ, Dept Zool, Mol Biol Lab, Patna 800005, Bihar, India
来源：
BIOLOGY BULLETIN | 2023年 / 50卷 / SUPPL 4期
关键词：
histone H3 clipping; proteases; chromatin; nucleosomes; TAIL;
D O I：
10.1134/S1062359022602294
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Histone H3 N-terminal tail (H3NT) clipping has been known for the last four decades, but its functional significance is still poorly understood. H3NT clipping has never received proper attention because it was thought that clipping is the result of the non-specific action of cellular proteases. However, in the last few years, several histone-specific proteases have been identified, and their functions have started to unravel. This paper discusses the recently identified H3-specific proteases, the consequences of histone clipping, and future perspectives.
引用
收藏
页码：S547 / S550
页数：4
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