The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed in human skin

被引：0
作者：
Clemens Weber
Jan Fischer
Lisa Redelfs
Franziska Rademacher
Jürgen Harder
Stephan Weidinger
Zhihong Wu
Ulf Meyer-Hoffert
机构：
[1] Universitätsklinikum Schleswig-Holstein,Department of Dermatology
[2] Zhejiang University of Science and Technology,Institute of Biochemistry and Cell Biology
来源：
Archives of Dermatological Research | 2017年 / 309卷
关键词：
Kallikrein-related peptidase; LEKTI; Psoriasis; Epidermis; Esophageal cancer-related gene; KLK; Protease inhibitor;
D O I：
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学科分类号：
摘要：
Proteases and their inhibitors play an important role in epidermal homeostasis. Their imbalance contributes to severe skin diseases. SPINK7 is a member of the SPINK protease inhibitor family and has been described so far as a cancer-related gene in the esophagus. Herein, we describe for the first time its expression in healthy human skin. Moreover, SPINK7 is up-regulated in inflammatory skin diseases like psoriasis and eczema as demonstrated by immunohistochemistry, though real-time PCR analyses revealed no significant up-regulation. In cultured keratinocytes, SPINK7 mRNA expression was up-regulated by IL-17A together with IFNγ. Our observation points to a role of SPINK7 in skin homeostasis and its involvement in inflammatory skin diseases.
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页码：767 / 771
页数：4
相关论文
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