ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males

被引：0
作者：
Leonard Abbeduto
Angela John Thurman
Andrea McDuffie
Jessica Klusek
Robyn Tempero Feigles
W. Ted Brown
Danielle J. Harvey
Tatyana Adayev
Giuseppe LaFauci
Carl Dobkins
Jane E. Roberts
机构：
[1] University of California,
[2] University of South Carolina,undefined
[3] New York State Institute for Basic Research in Developmental Disabilities,undefined
[4] UC Davis MIND Institute,undefined
来源：
Journal of Autism and Developmental Disorders | 2019年 / 49卷
关键词：
Fragile X syndrome; Autism spectrum disorder; Language; IQ; Psychiatric symptoms; FMRP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in the sample. There was less impairment in restricted and repetitive behaviors (RRB) than in the social affective (SA) domain. The best predictor of overall ASD severity and SA severity was expressive syntactic ability. RRB severity was best predicted by the psychiatric factors. Implications for clinical practice and for understanding the ASD comorbidity in FXS are discussed.
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页码：960 / 977
页数：17
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