Synthesis of (−)-neplanocin A analogues as potential antiviral agents

被引：0

作者：

Dae Hong Shin

Hyuk Woo Lee

Sung Soo Park

Joong Hyup Kim

Lak Shin Jeong

Moon Woo Chun

机构：

[1] Seoul National University,College of Pharmacy

[2] Korea Institute of Science and Technology,College of Pharmacy

[3] Ewha Womans University,undefined

来源：

Archives of Pharmacal Research | 2000年 / 23卷

关键词：

Neplanocin A; Nucleosides; Antiviral activity; Cytotoxicity; -adenosylhomocysteine hydrolase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Based on (-)-neplanocin A with the 5’-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo-and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.

引用

页码：302 / 309

页数：7

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