RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

被引：0
作者：
Xiaqiong Wang
Wei Jiang
Yiqing Yan
Tao Gong
Jiahuai Han
Zhigang Tian
Rongbin Zhou
机构：
[1] Institute of Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease,
[2] School of Life Sciences and Medical Center,undefined
[3] University of Science and Technology of China,undefined
[4] State Key Laboratory of Cellular Stress Biology,undefined
[5] School of Life Sciences,undefined
[6] Innovation Center for Cell Biology,undefined
[7] Xiamen University,undefined
[8] Xiamen,undefined
[9] Fujian,undefined
[10] China.,undefined
[11] Innovation Center for Cell Biology,undefined
[12] Hefei National Laboratory for Physical Sciences at Microscale,undefined
来源：
Nature Immunology | 2014年 / 15卷
关键词：
D O I：
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学科分类号：
摘要：
The mechanisms by which viruses activate the NLRP3 inflammasome remain unclear. Zhou and colleagues show that RNA viruses initiate a RIP1-RIP3 complex that drives mitochondrial damage and activation of the NLRP3 inflammasome independently of necrosis.
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页码：1126 / 1133
页数：7
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