In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy

被引:0
|
作者
Tanya Lynn Applegate
Donald John Birkett
Glen John Mcintyre
Angel Belisario Jaramillo
Geoff Symonds
John Michael Murray
机构
[1] Johnson and Johnson Research Pty Ltd,The National Centre in HIV Epidemiology and Clinical Research
[2] Level 4 Biomedical Building,School of Molecular and Microbial Biosciences, School of Biological Sciences
[3] University of New South Wales,School of Mathematics and Statistics
[4] University of Sydney,undefined
[5] Cell and Molecular Therapies,undefined
[6] Faculty of Medicine,undefined
[7] University of New South Wales,undefined
来源
关键词
Gene Therapy; Infected Cell; Chronic Granulomatous Disease; Resistant Virus; Uninfected Cell;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Rational development of a HIV-1 gene therapy vector
    Anson, DS
    Fuller, M
    JOURNAL OF GENE MEDICINE, 2003, 5 (10): : 829 - 838
  • [22] Relationship of Injection Drug Use, Antiretroviral Therapy Resistance, and Genetic Diversity in the HIV-1 pol Gene
    Kowalski, Jeanne
    Gange, Stephen J.
    Schneider, Michael F.
    Tsai, Hua-Ling
    Templeton, Alan
    Shao, Qiujia
    Zhan, Guang Wen
    Yeh, Mei-Fen
    Young, Mary
    Markham, Richard. B.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2009, 50 (04) : 381 - 389
  • [23] HIV-1 subtypes and drug resistance in children during antiretroviral therapy in Brazil
    de Andrade Arrais, Claudia R.
    Lima, Kledoaldo
    Barreiros, Marta
    Rodrigues, Jessyca K. F.
    Sousa, Nilviane P. S.
    Costa, Daniel D.
    Santos, Francisco D. R. P.
    Pereira, Gerson F. M.
    Silva Viana, Antonia I. e
    Barros, Allan K.
    Leal, Elcio
    JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (08) : 4908 - 4914
  • [24] HIV-1 Subtype and Virological Response to Antiretroviral Therapy: Acquired Drug Resistance
    Soares, Esmeralda A.
    Santos, Andre F.
    Soares, Marcelo A.
    CLINICAL INFECTIOUS DISEASES, 2012, 54 (05) : 738 - 738
  • [25] Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba
    Perez, Lissette
    Kouri, Vivian
    Aleman, Yoan
    Abrahantes, Yeisel
    Correa, Consuelo
    Aragones, Carlos
    Martinez, Orlando
    Perez, Jorge
    Fonseca, Carlos
    Campos, Jorge
    Alvarez, Delmis
    Schrooten, Yoeri
    Dekeersmaeker, Nathalie
    Imbrechts, Stijn
    Beheydt, Gertjan
    Vinken, Lore
    Soto, Yudira
    Alvarez, Alina
    Vandamme, Anne-Mieke
    Van Laethem, Kristel
    INFECTION GENETICS AND EVOLUTION, 2013, 16 : 144 - 150
  • [26] Recombination favors the evolution of drug resistance in HIV-1 during antiretroviral therapy
    Carvajal-Rodriguez, Antonio
    Crandall, Keith A.
    Posada, David
    INFECTION GENETICS AND EVOLUTION, 2007, 7 (04) : 476 - 483
  • [27] Targeting HIV:: antiretroviral therapy and development of drug resistance
    Menéndez-Arias, L
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (08) : 381 - 388
  • [28] Computational Models of HIV-1 Resistance to Gene Therapy Elucidate Therapy Design Principles
    Aviran, Sharon
    Shah, Priya S.
    Schaffer, David V.
    Arkin, Adam P.
    PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (08)
  • [29] Antiretroviral resistance in different HIV-1 subtypes: impact on therapy outcomes and resistance testing interpretation
    Camacho, Ricardo Jorge
    Vandamme, Anne-Mieke
    CURRENT OPINION IN HIV AND AIDS, 2007, 2 (02) : 123 - 129
  • [30] Impact of genetic diversity of HIV-1 on diagnosis, antiretroviral therapy & vaccine development
    Lal, RB
    Chakrabarti, S
    Yang, CF
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2005, 121 (04) : 287 - 314