Hodgkin's lymphoma presenting as a complex paraneoplastic neurological syndrome: A case report

被引：7

作者：

Ammannagari N. ^{[1
]}

Chikoti S. ^{[1
]}

Bravin E. ^{[2
]}

机构：

[1] Department of Internal Medicine, Bassett Medical Center, Cooperstown

[2] Division of Hematology and Oncology, Bassett Medical Center, Cooperstown

来源：

Journal of Medical Case Reports | / 7卷 / 1期

关键词：

Chronic Lymphocytic Leukemia; Small Cell Lung Cancer; Chronic Inflammatory Demyelinating Polyneuropathy; Paraneoplastic Neurological Syndrome; Cerebrospinal Fluid Analysis;

D O I：

10.1186/1752-1947-7-96

中图分类号：

学科分类号：

摘要：

Introduction. Paraneoplastic neuropathies are rare. They are often difficult to diagnose, especially when they precede the diagnosis of cancer. Hodgkin's lymphoma is associated with multiple paraneoplastic neurological syndromes, of which demyelinating polyneuropathies are very unusual. Association with chronic inflammatory demyelinating polyneuropathy is even more uncommon. Case presentation. We report the rare case of a 74-year-old Caucasian man who presented with a complex neurological syndrome and was eventually diagnosed with the nodular sclerosing variant of Hodgkin's lymphoma. With timely diagnosis and early institution of treatment of the underlying malignancy, our patient began to show gradual improvement of his symptoms. Conclusion: Hodgkin's lymphoma is associated with several paraneoplastic neurological syndromes. Sometimes it can be the only presenting feature of an underlying Hodgkin's lymphoma, posing a diagnostic challenge. Prompt oncologic treatment and immunotherapy can be beneficial if instituted early in the course of the disease. © 2013 Ammannagari et al.; licensee BioMed Central Ltd.

引用

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