Portal vein thrombosis associated with psoriasis: A case report

被引：4

作者：

Yudhishdran J.M. ^{[1
]}

Navinan R. ^{[1
]}

Jeyalakshmy S. ^{[2
]}

Ratnatilaka A. ^{[1
]}

机构：

[1] Department of Medicine, National Hospital of Sri Lanka, Regent Street, Colombo

[2] Department of Medicine, Colombo South Teaching Hospital, Colombo

来源：

BMC Research Notes | / 8卷 / 1期

关键词：

Portal vein thrombosis; Psoriasis; Venous thrombosis;

D O I：

10.1186/s13104-015-1046-7

中图分类号：

学科分类号：

摘要：

Background: Psoriasis is no longer viewed as an isolated dermatological ailment and instead is considered a systemic disease. The extension of this spectrum has heightened the known risk of morbidity and mortality due to the involvement of cardiovascular system and the risk of venous thrombosis. A number of cases have reported the increased occurrence of deep vein thrombosis and pulmonary embolism in the background of psoriasis, however portal vein thrombosis has not been reported to date. We report an index case of chronic portal vein thrombosis in a diagnosed patient with psoriasis. Case presentation: A 67-year-old South-Asian female previously diagnosed and treated for psoriasis presented with a four month history of abdominal pain associated with abdominal distension. Clinical examination revealed an enlarged spleen and free fluid in the abdomen. Imaging with ultrasonography and computed tomography of the abdomen revealed features compatible with chronic portal vein thrombosis with cavernous transformation. Conclusion: This case highlights the importance of having clinical awareness of occurrence of thrombosis in patients with psoriasis. Typical symptoms favoring thrombosis should prompt thorough investigation to exclude this rare yet possible complication in patients with psoriasis, including that of portal vein thrombosis. Prophylaxis with anticoagulation still lacks strength of evidence to be justified in psoriasis. The exact pathogenesis of venous thromboembolism in psoriasis is still unexplained and further studies are needed to clarify the causal association. © 2015 Yudhishdran et al.; licensee BioMed Central.

引用

共 27 条

[1]

Nestle F.O., Kaplan D.H., Barker J., Psoriasis, N Engl J Med., 361, pp. 496-509, (2009)

[2]

Menter A., Griffiths C.E., Current and future management of psoriasis, Lancet., 370, pp. 272-284, (2007)

[3]

Thomas J., Psoriasis: A Closer Look JP Medical Ltd, (2014)

[4]

Ridker P.M., Psoriasis, inflammation, and vascular risk: A problem more than skin deep?, Eur Heart J, 31, 8, pp. 902-904, (2010)

[5]

Ahlehoff O., Gislason G.H., Charlot M., Jorgensen C.H., Lindhardsen J., Olesen J.B., Et al., Psoriasis is associated with clinically significant cardiovascular risk: A Danish nationwide cohort study, J Intern Med., 270, pp. 147-157, (2011)

[6]

Ahlehoff O., Gislason G.H., Lindhardsen J., Charlot M.G., Jorgensen C.H., Olesen J.B., Et al., Psoriasis carries an increased risk of venous thromboembolism: A Danish nationwide cohort study, PLoS One., 6, (2011)

[7]

Ramagopalan S.V., Wotton C.J., Handel A.E., Yeates D., Goldacre M.J., Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: Record-linkage study, BMC Med., 9, (2011)

[8]

Vergou T., Moustou A.E., Maniateas A., Stratigos A.J., Katsambas A., Antoniou C., Central retinal vein occlusion following infliximab treatment for plaque-type psoriasis, Int J Dermatol., 49, pp. 1215-1217, (2010)

[9]

Al-Hashel J.Y., Ahmed S.F., Alexander K.J., Ahmed W., Cerebral Venous Thrombosis in a Patient with Clinically Isolated Spinal Cord Syndrome, Case Rep Neurological Med., 2013, (2013)

[10]

Bunch J.L., Psoriasis associated with Thrombosis of the Inferior Vena Cava, Proc R Soc Med., 7, pp. 257-258, (1914)

← 1 2 3 →