In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features

被引：0
作者：
Zhan Zhou
Yuhui Zheng
Cheng Cheng Zhang
Jinwei Gao
Yiping Tang
Qianming Wang
机构：
[1] Luoyang Normal University,College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function
[2] South China Normal University,Oriented Porous Materials
[3] University of Texas,Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry & Environment
[4] Southwestern Medical Center,Departments of Physiology and Developmental Biology
[5] South China Normal University,Guangdong Provincial Engineering Technology Research Center For Transparent Conductive Materials
[6] Zhejiang University of Technology,College of Material Science and Engineering
来源：
Photochemical & Photobiological Sciences | 2018年 / 17卷
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学科分类号：
摘要：
Carbonaceous materials have long been developed to utilize “nano-spaces” and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed. We have developed a theranostic platform based on photosensitizer-conjugated carbon nanostructures and this system has been applied in an animal model. In addition, a negligible toxicity of CNH-Pyro was found in body weight experiments and histopathological examination of the major organs.
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页码：1329 / 1336
页数：7
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