NAFLD in Women: Unique Pathways, Biomarkers, and Therapeutic Opportunities

被引：13
作者：
Yuan L. [1 ,2 ]
Kardashian A. [3 ]
Sarkar M. [3 ]
机构：
[1] Division of GI/Hepatology, University of Southern California, Los Angeles
[2] Health Sciences Campus, HCC 322W 1510 San Pablo Street, Los Angeles
[3] Division of Gastroenterology and Hepatology, University of California, San Francisco, Room S-357, 513 Parnassus Avenue, San Francisco, 94143-0358, CA
来源：
Current Hepatology Reports | 2019年 / 18卷 / 4期
关键词：
Hormones; Nonalcoholic fatty liver; Sex differences; Women;
D O I：
10.1007/s11901-019-00495-9
中图分类号：
学科分类号：
摘要：
Purpose of review: In this review article, we evaluate sex differences in the natural history of NAFLD and highlight distinct risk profiles of women with NAFLD, as well as unique treatment considerations and research gaps. Summary of Findings: Reproductive factors, such as menopausal status, should be considered when evaluating NAFLD risk in women, as well as additional reproductive risk factors such as age at menarche, presence of polycystic ovary syndrome, and gestational diabetes. Women do appear to have lower risk for hepatocellular carcinoma from NASH, as well as lower mortality from NASH cirrhosis than men, although among women, NASH is now the leading indication for liver transplant. Data on sex differences in biomarker development and clinical trials are lacking, and researchers should be encouraged to evaluate biomarker performance by sex, and specifically report clinical trial endpoints in women. © Springer Science+Business Media, LLC, part of Springer Nature 2019.
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收藏
页码：425 / 432
页数：7
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