Animal models of multiple system atrophy

被引：0
作者：
Nadia Stefanova
Gregor K. Wenning
机构：
[1] Innsbruck Medical University,Division of Neurobiology, Department of Neurology
来源：
Clinical Autonomic Research | 2015年 / 25卷
关键词：
α-Synuclein; Parkinsonism; Cardiovascular failure; Urinary dysfunction; Olivopontocerebellar atrophy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Since their introduction in 1996, animal models of multiple system atrophy (MSA) have generated important insights into pathogenesis and interventional therapies. Toxin and genetic approaches have been used alone or in combination to replicate progressive motor and non-motor symptoms reflecting human neuropathology. Here, we review these developments and discuss the advantages and limitations of the MSA animal models, as well as their application in preclinical target validation.
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页码：9 / 17
页数：8
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