Structure-Based Drug Design of RdRp Inhibitors against SARS-CoV-2

被引：0

作者：

Kiran Shehzadi

Afsheen Saba

Mingjia Yu

Jianhua Liang

机构：

[1] Beijing Institute of Technology,Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering

[2] Yangtze Delta Region Academy of Beijing Institute of Technology,undefined

来源：

Topics in Current Chemistry | 2023年 / 381卷

关键词：

RdRp; SARS-CoV-2; RdRp inhibitors; COVID-19; Therapeutic target;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Exploring the potential clinical targets for attenuating coronavirus disease 2019 (COVID-19) by structure-based drug designing of RdRp inhibitors.RdRp catalytic site and druggable cavities predictions of SARS-CoV-2.Pharmacophoric features and structure–activity relationship analysis of different repurposed therapeutic drugs for COVID-19 against RdRp of SARS-CoV-2.Current treatments are logistically challenging, increasing the need for safe and effective oral therapies.Ongoing global efforts to prevent the spread of COVID-19 disease and the current status of SARS-CoV-2.

引用

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