Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

被引:0
作者
Michelle van Geldermalsen
Lake-Ee Quek
Nigel Turner
Natasha Freidman
Angel Pang
Yi Fang Guan
James R. Krycer
Renae Ryan
Qian Wang
Jeff Holst
机构
[1] University of Sydney,Origins of Cancer Program, Centenary Institute
[2] University of Sydney,Sydney Medical School
[3] University of Sydney,School of Mathematics and Statistics
[4] University of New South Wales,School of Medical Sciences
[5] University of Sydney,Transporter Biology Group, Discipline of Pharmacology, Faculty of Medicine and Health
[6] University of Sydney,School of Life and Environmental Sciences
[7] University of Sydney,Charles Perkins Centre
来源
BMC Cancer | / 18卷
关键词
Amino acids; Metabolism; Triple-negative; Luminal A; Stress response;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 364 条
[1]  
Babu E(2003)Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters J Biol Chem 278 43838-43845
[2]  
Kanai Y(2005)Identification of LAT4, a novel amino acid transporter with system L activity J Biol Chem 280 12002-12011
[3]  
Chairoungdua A(1999)Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids J Biol Chem 274 19738-19744
[4]  
Kim DK(1999)Identification and functional characterization of a Na+−independent neutral amino acid transporter with broad substrate selectivity J Biol Chem 274 19745-19751
[5]  
Iribe Y(2015)L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia Am J Cancer Res 5 1281-1294
[6]  
Tangtrongsup S(2011)Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression Cancer Res 71 7525-7536
[7]  
Jutabha P(2013)Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development J Natl Cancer Inst 105 1463-1473
[8]  
Li Y(2014)Targeting glutamine transport to suppress melanoma cell growth Int J Cancer 135 1060-1071
[9]  
Ahmed N(2013)SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival Clin Cancer Res 19 560-570
[10]  
Sakamoto S(2015)Targeting SLC1A5-mediated glutamine dependence in non-small cell lung cancer Int J Cancer 137 1587-1597