Endocrine disruption induced by bisphenol A in young and adult female Sprague Dawley rats

被引：0

作者：

Hamdy H. ^{[1
]}

Yahia D. ^{[2
]}

Afifi S. ^{[3
]}

Salem D.A. ^{[2
]}

机构：

[1] Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, New Valley

[2] Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut

[3] Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut

来源：

Comparative Clinical Pathology | 2018年 / 27卷 / 4期

关键词：

Bisphenol A; Endocrine disruption; Female hormones; Histopathology; Ovaries;

D O I：

10.1007/s00580-018-2689-2

中图分类号：

学科分类号：

摘要：

Bisphenol A (BPA) is involved chemically in the production of some plastics and as a coating for the inner surface of food containers. The current work aimed to investigate the endocrine-disrupting effect of BPA in young and adult female Sprague Dawley rats. Young and adult female rats were exposed orally to 330 mg/kg body weight of BPA dissolved in ethyl alcohol and suspended in corn oil, day after day for 12 weeks. Control rats dosed orally by the solvent only. The samples were collected every 2 weeks for hormonal assays and histopathological examination. The hormonal assays revealed that there was an increase in estradiol concentration in young female; however, in adult ones, estradiol concentration was decreased after 10 and 12 weeks. Progesterone concentration was decreased in adult ones only at 4 weeks, while testosterone hormone was increased in young female rats. The histopathological finding revealed that there were polycystic follicles in the ovaries of young female, while in adult ones, there were atretic follicles. In conclusion, BPA exposure resulted in endocrine disruption indicated by different responses in hormonal and histopathological changes in both young and adult female rats. © 2018, Springer-Verlag London Ltd., part of Springer Nature.

引用

页码：967 / 974

页数：7

共 52 条

[1]

Adewale H.B., Jefferson W.N., Newbold R.R., Patisaul H.B., Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons, Biol Reprod, 81, pp. 690-699, (2009)

[2]

Beronius A., Ruden C., Hakansson H., Hanberg A., Risk to all or none? A comparative analysis of controversies in the health risk assessment of bisphenol A, Reprod Toxicol, 29, pp. 132-146, (2010)

[3]

Boone D.L., Tsang B.K., Caspase-3 in the rat ovary: localization and possible role in follicular atresia and luteal regression, Biol Reprod, 58, pp. 1533-1539, (1998)

[4]

Cabaton N.J., Wadia P.R., Rubin B.S., Zalko D., Schaeberie C.M., Askenase M.H., Perinatal exposure to environmental relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice, Environ Health Perspect, 119, pp. 547-552, (2011)

[5]

Calafat A.M., Kuklenyik Z., Reidy J.A., Caudill S.P., Ekong J., Needham L.L., Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population, Environ Health Perspect, 113, pp. 391-395, (2004)

[6]

Chen D., Kannan K., Tan H., Zheng Z., Feng Y.L., Wu Y., Widelka M., Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity—a review, Environ Sci Technol, 50, 11, pp. 5438-5453, (2016)

[7]

Chen W., Lau S.W., Fan Y., Wu R.S.S., Ge W., Juvenile exposure to bisphenol A promotes ovarian differentiation but suppresses its growth—potential involvement of pituitary follicle-stimulating hormone, Aquat Toxicol, 193, pp. 111-121, (2017)

[8]

Delclos K.B., Camacho L., Lewis S.M., Vanlandingham M.M., Latendresse JR, Olson GR. Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90, Toxicol Sci, 139, pp. 174-197, (2013)

[9]

Dominguez M.A., Petre M.A., Neal M.S., Foster W.G., Bisphenol A concentration-dependently increases human granulosa-lutein cell matrix metalloproteinase-9 (MMP-9) enzyme output, Reprod Toxicol, 25, pp. 420-425, (2008)

[10]

Fernandez M., Bourguignon N., Lux-Lantos V., Libertun C., Neonatal exposure to bisphenol A and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats, Environ Health Perspect, 118, pp. 1217-1222, (2010)

← 1 2 3 4 5 6 →