The effect of a modified etidronate cyclical regimen on postmenopausal osteoporosis: A four-year study

被引：0
作者：
G. P. Lyritis
N. Tsakalakos
I. Paspati
Gr. Skarantavos
A. Galanos
C. Androulakis
机构：
[1] University of Athens,Laboratory for the Research of Musculoskeletal System
[2] KAT Hospital,undefined
来源：
Clinical Rheumatology | 1997年 / 16卷
关键词：
Bone Mineral Density; Etidronate; 1,25-dihydroxyvitamin D; Postmenopausal Osteoporosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To develop an improved treatment schedule for osteoporosis, a study was undertaken in 100 postmenopausal women using a modified ADFR 90-day cyclical regimen with etidronate. After one year of treatment, the etidronate-treated group showed a significant increase in bone density of the spine, which continued over the following 2 years of treatment and remained stable during the fourth year. In contrast, in the non-etidronate group, bone density decreased significantly after four years. In addition, the fracture rate was significantly lower in the etidronate group than in the non-etidronate group. Side effects were minimal in both groups and no serious adverse reactions were reported. In conclusion, it appears that a cyclical regimen using 1,25-dihydroxyvitamin D3, etidronate and calcium increases bone mass and reduces fractures with no significant side effects, thus making a useful contribution in the treatment of postmenopausal osteoporosis.
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页码：354 / 360
页数：6
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