Antigen and Memory CD8 T Cells: Were They Both Right?

被引：0
作者：
Slava Epelman
Christopher H Mody
机构：
[1] Cleveland Clinic,Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, AB; currently Department of Internal Medicine
[2] University of Calgary,Departments of Microbiology and Infectious Diseases and Internal Medicine
来源：
Allergy, Asthma & Clinical Immunology | / 3卷 / 2期
关键词：
antigen; CD8 cells; central memory; effector memory;
D O I：
10.1186/1710-1492-3-2-37
中图分类号：
学科分类号：
摘要：
Picture yourself as a researcher in immunology. To begin your project, you ask a question: Do CD8 T cells require antigen to maintain a memory response? This question is of prime importance to numerous medical fields. In chronologic order, you digest the literature, but unfortunately, you hit a major stumbling block in the 1990s. The crux of the problem is that which so often happens in science: two well-recognized, capable groups emerge with diametrically opposed conclusions, leaving you pondering which set of wellcontrolled data to believe. Fortunately, years later, a surprising group of articles sheds light on this mystery and subtly reconciles these two positions.
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