Physiological Changes During the Menstrual Cycle and Their Effects on the Pharmacokinetics and Pharmacodynamics of Drugs

被引:0
作者
Angela D. M. Kashuba
Anne N. Nafziger
机构
[1] Bassett Healthcare,Clinical Pharmacology Research Center
[2] Bassett Healthcare,Department of Medicine
来源
Clinical Pharmacokinetics | 1998年 / 34卷
关键词
Adis International Limited; Menstrual Cycle; Atrial Natriuretic Peptide; Luteal Phase; Antipyrine;
D O I
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学科分类号
摘要
There is an increasing awareness that the exclusion of women from clinical trials may lead to inaccurate application of drug therapy in women. Gender and estrus cycle differences in the pharmacokinetics and pharmacodynamics of drugs in animals have been appreciated for over 60 years, but investigation into these differences in humans has only recently occurred.
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页码:203 / 218
页数:15
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