Synthesis of a C-2 Stapled Bis-Lexitropsin

被引：0

作者：

Naim H. Al-Said

Sami Klaib

机构：

[1] Jordan University of Science and Technology,Department of Applied Chemical Sciences, Faculty of Science

[2] Tafila Technical University,Department of Chemistry

来源：

Monatshefte für Chemie - Chemical Monthly | 2007年 / 138卷

关键词：

Keywords. Synthesis; Homodimeric; Bis-lexitropsin; Minor groove.;

D O I：

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中图分类号：

学科分类号：

摘要：

A convenient synthesis method was developed for the preparation of C-stapled homodimeric bis-lexitropsins connected through the nitrogen atoms of the central pyrrole ring with a bis-methylene linker. This lexitropsin is designed as a standard for other bis-lexitropsins with longer chains in biological evaluation and NMR studies. The key step in this method is the treatment of ethyl 4-nitropyrrole-2-carboxylate with flame-dried potassium carbonate in DMF followed by the addition of 1,2-dibromoethane to form the 1,2-dipyrroloethane derivative.

引用

页码：573 / 577

页数：4

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