Low-dose compared to manufacturer-recommended dose four-factor prothrombin complex concentrate for acute warfarin reversal

[1] Goldstein JN(2015)Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial Lancet 385 2077-2087

[2] Refaai MA(2013)Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study Circulation 128 1234-1243

[3] Milling TJ(2016)Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the neurocritical care society and society of critical care medicine Neurocrit Care 24 6-46

[4] Lewis B(2012)Evidence-based management of anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines Chest 141 e152S-e184S

[5] Goldberg-Alberts R(2017)2017 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants: a report of the american college of cardiology task force on expert consensus decision pathways J Am Coll Cardiol 70 3042-3067

[6] Hug BA(2012)An observational, prospective, two-cohort comparison of a fixed versus variable dosing strategy of prothrombin complex concentrate to counteract vitamin K antagonists in 240 bleeding emergencies Haematologica 97 1501-1506

[7] Sarode R(2013)The effectiveness and safety of fixed low-dose prothrombin complex concentrates in patients requiring urgent reversal of warfarin Transfusion 53 1451-1458

[8] Sarode R(2005)Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation Thromb Res 115 455-459

[9] Milling TJ(2011)Fixed versus variable dose of prothrombin complex concentrate for counteracting vitamin K antagonist therapy Transfus Med 21 116-123

[10] Refaai MA(2016)Thrombotic complications following the administration of high-dose prothrombin complex concentrate for acute warfarin reversal Am J Emerg Med 34 1736 e1731-e1733

[1] Goldstein JN(2015)Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial Lancet 385 2077-2087

[2] Refaai MA(2013)Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study Circulation 128 1234-1243

[3] Milling TJ(2016)Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the neurocritical care society and society of critical care medicine Neurocrit Care 24 6-46

[4] Lewis B(2012)Evidence-based management of anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines Chest 141 e152S-e184S

[5] Goldberg-Alberts R(2017)2017 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants: a report of the american college of cardiology task force on expert consensus decision pathways J Am Coll Cardiol 70 3042-3067

[6] Hug BA(2012)An observational, prospective, two-cohort comparison of a fixed versus variable dosing strategy of prothrombin complex concentrate to counteract vitamin K antagonists in 240 bleeding emergencies Haematologica 97 1501-1506

[7] Sarode R(2013)The effectiveness and safety of fixed low-dose prothrombin complex concentrates in patients requiring urgent reversal of warfarin Transfusion 53 1451-1458

[8] Sarode R(2005)Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation Thromb Res 115 455-459

[9] Milling TJ(2011)Fixed versus variable dose of prothrombin complex concentrate for counteracting vitamin K antagonist therapy Transfus Med 21 116-123

[10] Refaai MA(2016)Thrombotic complications following the administration of high-dose prothrombin complex concentrate for acute warfarin reversal Am J Emerg Med 34 1736 e1731-e1733