Do women with statin-related myalgias have low Vitamin D levels?

被引：6

作者：

Minissian M. ^{[1
]}

Agarwal M. ^{[1
]}

Shufelt C. ^{[1
]}

Mehta P.K. ^{[1
]}

Waldman T. ^{[1
]}

Lentz G. ^{[1
]}

Cook-Wiens G. ^{[1
]}

Eastwood J.-A. ^{[1
]}

Noel Bairey Merz C. ^{[1
]}

机构：

[1] Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 San Vicente Blvd AHSP, Los Angeles, 90048, CA

来源：

BMC Research Notes | / 8卷 / 1期

关键词：

Alternative statin dosing; Myalgia; Statin; Statin intolerance; Vitamin D;

D O I：

10.1186/s13104-015-1356-9

中图分类号：

学科分类号：

摘要：

Background: Statin intolerance is often due to myalgias. Severe vitamin D deficiency is characterized by musculoskeletal pain. We hypothesized that statin-intolerance is associated with vitamin D deficiency. Objectives: To determine whether there is an association between statin-intolerance and vitamin D deficiency in a retrospective observational analysis. Methods: We evaluated 20 female patients with prior myalgia-related daily dose statin intolerance on an alternative day statin dosing protocol of twice weekly for 4 weeks followed by advancement to daily dosing, as tolerated. Fasting baseline and follow-up lipid and 25-hydroxy-vitamin D (25-OHD) levels were obtained by chart review. Results: The group median age was 61 ± 13 years old and BMI was 27 ± 7 kg/m2. Women who remained on alternative day statin dosing (n = 16) compared to women on daily dosing (n = 4) had a significantly lower group mean 25-OHD (mean 29 ± 11.23 vs. 47.5 ± 23.53 ng/ml p = 0.0307 respectively). Conclusions: In women with prior myalgia-related statin intolerance, vitamin D levels were significantly lower in women who remained on alternative day dosing compared to those who were tolerant of daily dosing. © 2015 Minissian et al.

引用

共 17 条

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